Retrieved data for study published on BMJ Open: "Methodological standards, quality of reporting, and regulatory compliance in animal research on amyotrophic lateral sclerosis: a systematic review"

Excel file with four sheets, the first with data number-coded for SPSS, the second with data labels, the third with data for group size calculation for the preclinical studies subset, and a fourth with data gathered to estimate trends in animal model of choice in ALS research.

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Author Nuno Henrique Franco
Last Updated March 8, 2019, 11:18 (UTC)
Created March 6, 2019, 14:05 (UTC)
dc.Author Nuno Henrique Franco, Joana G Fernandes, Andrew J Grierson, Jan Hultgren, Andrew JW Furley e I. Anna S. Olsson
dc.Contributor i3S - Instituto de Investigação e Inovação em Saúde
dc.Date Created 2013-2016
dc.Format xlsx file
dc.Language English
dc.Publisher University of Porto Data Repository
dc.Relation Scientific paper: "Methodological standards, quality of reporting, and regulatory compliance in animal research on amyotrophic lateral sclerosis: a systematic review". BMJ
dc.Spatial Coverage Papers published on the SOD-1 mouse model of ALS in odd years between 2005 and 2015, retrieved from the ISI Web of Science database
dc.Temporal Coverage Search performed in Feb 2013 for scientific articles from 2009 and 2011, in August 2013 for scientific articles from 2005, in September 2014 for scientific articles from 2013, in November 2016 for scientific articles from 2015, and in February 2017 for scientific articles from 2007
dc.Type Data systematically retrieved from reading sample of ALS papers, following predefined data extraction protocol
ddi.Data Collection Methodology Each published study was categorised as either a ‘preclinical’ (i.e., carried out “to evaluate a drug for use in humans”) or ‘proof-of-concept’ (i.e., aiming “to elucidate the mechanism of the disease”), according to the suggested classification for animal studies on ALS 2 38. Table 1 describes the information retrieved regarding regulatory compliance, animal models, experimental design and animal welfare. This information was retrieved through careful reading of the full papers. The review protocol was defined prior to data collection. No modifications to data collection methods were made during the research, but the period to be covered was extended to include publication year 2015
ddi.Instrument Name "ISI Web of Science", currently "Clarivate analytics Web of Science"
ddi.Research Domain Systematic review of methodological standards and animal welfare in animal research on ALS
ddi.Sample Scientific articles reporting studies on the SOD-1 mouse model of ALS (N=569)
ddi.Sampling Procedure The sample comprises scientific articles (published in English), retrieved by an advanced search carried out on the ISI Web of Science® database with the query <<TS = ((mice OR mouse) SAME (ALS OR “amyotrophic lateral sclerosis”))>>
ddi.Type of Instrument Scientific citation indexing service search engine and database